Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

, … Based Study Consortium, Alzheimer's Disease … - Molecular …, 2021 - nature.com
… We now report a large genome-wide association meta-analysis of 12,317 AD subjects with
and without psychosis. We identified two loci with genome-wide significant associations with …

[HTML][HTML] Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank

C Gouveia, E Gibbons, N Dehghani, J Eapen… - Scientific Reports, 2022 - nature.com
genome-wide association studies (GWAS) have greatly improved the statistical power to detect
novel genetic associations … can be observed with psychiatric traits such as schizophrenia, …

Exploring genetic risk for catatonia in a genome wide association study and polygenic risk score analysis

JE Wilson, J Sealock, P Straub, R Raman… - … Research, 2023 - Elsevier
genome wide association study of catatonia regardless of etiology (psychiatric or non-psychiatric
had a code for Alzheimer's Disease or obsessive compulsive disorder, respectively. …

[HTML][HTML] Multi-trait analysis for genome-wide association study of five psychiatric disorders

Y Wu, H Cao, A Baranova, H Huang, S Li, L Cai… - Translational …, 2020 - nature.com
… We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia
(SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n …

Genetics of resilience: Implications from genomewide association studies and candidate genes of the stress response system in posttraumatic stress disorder and …

S Maul, I Giegling, C Fabbri, F Corponi… - American Journal of …, 2020 - Wiley Online Library
psychiatric disorders such as posttraumatic stress disorder (PTSD) and major depressive
disorder (MDD… A recently published genomewide association study (GWAS) on resilience has …

[HTML][HTML] Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

DF Levey, M Galimberti, JD Deak, FR Wendt… - Nature Genetics, 2023 - nature.com
… Here we performed a genome-wide association study of … We discovered genome-wide
significant loci unique to each … and psychiatric public health consequences that require further …

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

MA Waszczuk, KG Jonas, M Bornovalova… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body of …

[HTML][HTML] A genome-wide association study for melatonin secretion

PH Liu, GT Chuang, CN Hsiung, WS Yang, HC Ku… - Scientific Reports, 2022 - nature.com
… Individuals with a record of neurological disorders or psychiatric illnesses were excluded …
Patients with neurodegenerative disorder such as Alzheimer's disease exhibit reduced serum …

[HTML][HTML] A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders

IS Bhatt, N Wilson, R Dias, A Torkamani - Scientific reports, 2022 - nature.com
… accompanied by psychiatric comorbidities. Recent genome-wide association studies (GWAS) …
A shared genetic component between tinnitus and psychiatric conditions remains elusive. …

Pervasive downward bias in estimates of liability-scale heritability in genome-wide association study meta-analysis: a simple solution

AD Grotzinger, J de la Fuente, F Privé, MG Nivard… - Biological …, 2023 - Elsevier
… We went on to examine the differences in estimates obtained from these 2 approaches
for real data for 12 major case-control genome-wide association studies of psychiatric and …